Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2022, vol. 59, nr 4, October-December, p. 565–571

doi: 10.17219/dmp/145593

Publication type: original article

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Patil RS, Kalburgi NB, Koregol AC, Vinayaka AM, Puttarevanna T, Hannahson P. Effect of non-surgical periodontal therapy on the salivary levels of omentin-1, a novel adipokine biomarker in periodontitis: A clinico-biochemical study. Dent Med Probl. 2022;59(4):565–571. doi:10.17219/dmp/145593

Effect of non-surgical periodontal therapy on the salivary levels of omentin-1, a novel adipokine biomarker in periodontitis: A clinico-biochemical study

Ruchita Sunil Patil1,A,B,C,D,E,F, Nagaraj Balasaheb Kalburgi2,A,C,F, Arati Chanabasappa Koregol2,A,B,C,D,E,F, Ambujakshi Manjunatha Vinayaka2,C,D,E,F, Tejashwini Puttarevanna1,B, Puladas Hannahson1,B

1 Postgraduate student, Department of Periodontics, P.M.N.M. Dental College and Hospital, Bagalkot, India

2 Department of Periodontics, P.M.N.M. Dental College and Hospital, Bagalkot, India

Abstract

Background. Biomarkers are emerging, advanced diagnostic tools for the assessment of periodontal disease progression. Omentin-1 is an anti-inflammatory adipocytokine, which has been observed and studied in the saliva of periodontitis patients. Non-surgical periodontal therapy (NSPT) is considered a vital part of periodontal disease treatment.
Objectives. The study aimed to evaluate the interventional effect of NSPT on the levels of salivary omentin1 in healthy (H) and chronic periodontitis (CP) patients.
Material and methods. A total of 60 participants were selected and equally divided into 2 groups (group A: H participants, group B: CP patients). After obtaining verbal and written consent, whole unstimulated saliva was collected from all participants and analyzed for omentin-1 levels using enzyme-linked immunosorbent assay (ELISA).
Results. Mean salivary omentin-1 levels were elevated and found to be significantly higher in group A (95.80 ±26.65) compared to group B (61.97 ±24.53). In group B, there was a substantial rise in omentin1 levels from baseline to the 6th week of follow-up (p < 0.001). Thus, NSPT had a positive influence on salivary omentin-1 levels in the treatment group.
Conclusions. Salivary omentin-1 levels may serve as diagnostic and prognostic indicators of periodontal disease progression, and may be used to assess therapeutic outcomes in periodontitis patients.

Key words

omentin-1, periodontitis, saliva, biomarker, non-surgical periodontal therapy

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