Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2020, vol. 57, nr 3, July-September, p. 327–332

doi: 10.17219/dmp/119998

Publication type: clinical case

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Osteopetrosis complicated by osteomyelitis of the maxilla: A rare case report and review of the literature

Osteopetroza powikłana zapaleniem szpiku szczęki – opis rzadkiego przypadku i przegląd piśmiennictwa

Moegamat Sallies1,A,B,C,D,F, Fadi Titinchi1,A,B,D,F, Jean Morkel1,A,D,E,F

1 Department of Maxillofacial and Oral Surgery, Faculty of Dentistry and WHO Collaborating Center, University of the Western Cape, Cape Town, South Africa


Osteopetrosis is a rare hereditary bone disorder that results in an increase in bone density due to gene mutations and osteoclastic dysfunction. This may lead to cranial nerve compression, bone fractures and osteomyelitis. Osteomyelitis of the maxilla is rare even in osteopetrosis patients. We report on a case of a 25-year-old male who presented with multiple episodes of osteomyelitis of the maxilla following dental extractions. The patient was initially managed with the incision and drainage of an acute infection, and intravenous amoxicillin-clavulanic acid. This was followed by the debridement of necrotic bony margins and packing with bismuth iodoform paraffin paste (BIPP) as well as long-term clindamycin. Once osteomyelitis was clear, the primary closure was achieved with a buccal advancement flap and supported by an acrylic obturator. Challenges in the management are highlighted, including preparing for a surgical intervention a patient with chronic low hemoglobin levels and a lack of healthy bony margins in the maxilla. The literature is also reviewed for similar cases.

Key words

osteomyelitis, maxilla, osteopetrosis

Słowa kluczowe

zapalenie szpiku, szczęka, osteopetroza

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