Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2020, vol. 57, nr 3, July-September, p. 295–304

doi: 10.17219/dmp/120991

Publication type: review article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Pharmacological and non-pharmacological management of burning mouth syndrome: A systematic review

Leczenie farmakologiczne i niefarmakologiczne zespołu pieczenia jamy ustnej – przegląd piśmiennictwa

Ayman Antoun Reyad1,A,B,D,E, Raafat Mishriky2,A,C,D, Eriny Girgis3,A,C,D

1 School of Pharmacy, University of Wolverhampton, UK

2 Old Age Psychiatry, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK

3 Community Dental Service, Coventry and Warwickshire Partnership NHS Trust, Coventry, UK


Burning mouth syndrome (BMS) is idiopathic chronic oral pain, associated with depression, anxiety and pain symptoms. The BMS symptoms include a burning sensation in the tongue and/or other oral mucosa with no underlying medical or dental reasons. As many BMS patients suffer from psychiatric comorbidities, several psychotropic drugs are included in the management of BMS, reducing the complaint, while managing anxiety, depression and pain disorders. In this review, a search of the published literature regarding the management of BMS was conducted. We discuss the BMS etiology, clinically associated symptoms and available treatment options. The current evidence supports some BMS interventions, including alpha-lipoic acid (ALA), clonazepam, capsaicin, and low-level laser therapy (LLLT); however, there is a lack of robust scientific evidence, and large-scale clinical trials with long follow-up periods are needed to establish the role of these BMS management options. This knowledge could raise the awareness of dentists, psychiatrists and general practitioners about these challenges and the available kinds of treatment to improve multidisciplinary management for better health outcomes.

Key words

burning mouth syndrome, neuropathic pain, orofacial pain, clonazepam, oral conditions

Słowa kluczowe

zespół pieczenia jamy ustnej, ból neuropatyczny, ból twarzoczaszki, klonazepam, warunki w jamie ustnej

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