Dental and Medical Problems

Dent Med Probl
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Dental and Medical Problems

2020, vol. 57, nr 3, July-September, p. 233–238

doi: 10.17219/dmp/119937

Publication type: original article

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Histologic grading of the tumor/tissue interface to predict lymph node metastasis in squamous cell carcinoma of the tongue

Histologiczne stopnie złośliwości tkanki nowotworowej a predykcja przerzutowania do węzłów chłonnych w raku płaskonabłonkowym języka

Ranjith Shetty1,A,B,C,D,E,F

1 Department of Oral Pathology and Microbiology, A.B. Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangalore, India

Abstract

Background. The invasive front is presumed to contain the most aggressive subpopulation of tumor cells that ultimately invade, spread locally and metastasize. Studying the histopathological grading of the tumor/ tissue interface at the invasive front may help in developing the treatment plan.
Objectives. The aim of this study was to check the reliability of the tumor/tissue interface in predicting lymph node metastasis in oral squamous cell carcinoma (OSCC) of the tongue by evaluating the following: the histopathological grading of hematoxylin and eosin (H&E)-stained excision biopsy specimens according to the modified version of Broder’s classification system; and the invasive tumor front (ITF) with the modified version of Bryne’s grading system. The study also aimed at studying the lymph nodes for metastases and comparing these histopathological grading systems and lymph node metastases.
Material and Methods. All retrospective and prospective cases from the archives of the Department of Oral Pathology and Microbiology of the A.B. Shetty Memorial Institute of Dental Sciences (ABSMIDS), NITTE University in Mangalore, India, collected during the period from 2012 to 2014 were considered for histopathological grading.
Results. This study found a significant association between the modified version of Bryne’s ITF grading system and lymph node metastases whereas the widely used modified version of Broder’s classification failed to show any statistical significance. Only the multifactorial malignancy grading of the deep invasive margins of OSCC proved to be of high prognostic value.
Conclusion. The study found that the degree of keratinization, nuclear polymorphism, the pattern of invasion, and the host response showed significant variation at the invasive front of the tumor as compared to superficial parts, which makes Bryne’s grading system more reliable than Broder’s grading system.

Key words

lymph node metastasis, oral squamous cell carcinoma of the tongue, Broder’s grading, Bryne’s grading, invasive tumor front

Słowa kluczowe

przerzutowanie do węzłów chłonnych, rak płaskonabłonkowy języka, stopniowanie złośliwości wg Brodera, stopniowanie złośliwości wg Bryne’a, inwazyjny front raka

References (24)

  1. Bello IO, Soini Y, Salo T. Prognostic evaluation of oral tongue cancer: Means, markers and perspectives (II). Oral Oncol. 2010;46(9):636–643.
  2. Nicoara M, Bain K, Patel R, Jaikaran O, Hingorani A, Asher E. Malignant transformation of non-healing ulcer-basal cell carcinoma. Ann Vasc Surg. 2020;S0890–5096(20)30156–4.
  3. Cho JK, Hyun SH, Choi N, et al. Significance of lymph node metastasis in cancer dissemination of head and neck cancer. Translat Oncol. 2015;8(2):119–125.
  4. Akhter M, Hossain S, Rahman QB, Molla MR. A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis. J Oral Maxillofac Pathol. 2011;15(2):168–176.
  5. Dissanayake U. Malignancy grading of invasive fronts of oral squamous cell carcinomas: Correlation with overall survival. Transl Res Oral Oncol. 2017;2(1):1–8.
  6. Chang YC, Nieh S, Chen SF, Jao SW, Lin YL, Fu E. Invasive pattern grading score designed as an independent prognostic indicator in oral squamous cell carcinoma. Histopathology. 2010;57(2):295–303.
  7. Broder AC. Carcinoma of the mouth: Types and degrees of malignancy. Am J Roentgenol Radium Ther Nucl Med. 1927;17:90–93.
  8. Bryne M, Koppang HS, Lilleng R, Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol. 1992;166(4):375–381.
  9. Singh MP, Kumar V, Agarwal A, Kumar R, Bhatt MLB, Misra S. Clinico-epidemiological study of oral squamous cell carcinoma: A tertiary care centre study in North India. J Oral Biol Craniofac Res. 2016;6(1):31–34.
  10. Doshi NP, Shah SA, Patel KB, Jhabuawala MF. Histological grading of oral cancer: A comparison of different systems and their relation to lymph node metastasis. Nat J Community Med. 2011;2(1):136–142.
  11. Markopoulos AK. Current aspects on oral squamous cell carcinoma. Open Dent J. 2012;6:126–130.
  12. Burusapat C, Jarungroongruangchai W, Charoenpitakchai M. Prognostic factors of cervical node status in head and neck squamous cell carcinoma. World J Surg Oncol. 2015;13(1):51–62.
  13. Jadhav KB, Gupta N. Clinicopathological prognostic implicators of oral squamous cell carcinoma: Need to understand and revise. N Am J Med Sci. 2013;5(12):671–679.
  14. Kapoor C, Vaidya S, Wadhwan V, Malik S. Lymph node metastasis: A bearing on prognosis in squamous cell carcinoma. Indian J Cancer. 2015;52(3):417–424.
  15. De Silva RK, Siriwardena BSMS, Samaranayaka A, Abeyasinghe WAMUL, Tilakaratne WM. A model to predict nodal meta­stasis in patients with oral squamous cell carcinoma. PloS One. 2018;13(8):e0201755.
  16. Odell EW, Jani P, Ahluwalia SM, Hibbert J, Levison DA, Morgan PR. The prognostic value of individual histologic grading parameters in small lingual squamous cell carcinomas. The importance of the pattern of invasion. Cancer. 1994;74(3):789–794.
  17. Jamadar S, Narayan TV, Shreedhar B, Mohanty L, Shenoy S. Comparative study of various grading systems in oral squamous cell carcinoma and their value in predicting lymph node metastasis. Indian J Dent Res. 2014;25(3):357–363.
  18. Jakobsson PA, Eneroth CM, Killander D, Moberger G, Mårtensson B. Histologic classification and grading of malignancy in carcinoma of the larynx. Acta Radiol Ther Phys Biol. 1973;12(1):1–8.
  19. Bryne M, Koppang HS, Lilleng R, Stene T, Bang G, Dabelsteen E. New malignancy grading is a better prognostic indicator than Broder’s grading in oral squamous cell carcinomas. J Oral Pathol Med. 1989;18(8):432–437.
  20. Sharma M, Sah P, Sharma SS, Radhakrishnan R. Molecular changes in invasive front of oral cancer. J Oral Maxillofac Pathol. 2013;17(2):240–247.
  21. Monevska DP, Janevska V, Naumovski S, et al. Multiple pathohistological parameters influencing prognosis and survival of oral cancer patients. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2013;34(2):169–174.
  22. Khwaja T, Tayaar AS, Acharya S, Bhushan J, Muddapur MV. Pattern of invasion as a factor in determining lymph node metastasis in oral squamous cell carcinoma. J Cancer Res Ther. 2018;14(2):382–387.
  23. Bryne M, Nielsen K, Koppang HS, Dabelsteen E. Reproducibility of two malignancy grading systems with reportedly prognostic value for oral cancer patients. J Oral Pathol Med. 1991;20(8):369–372.
  24. Nadaf A, Bavle RM, Soumya M, D’mello S, Kuriakose MA, Govindan S. Analysis of the invasive edge in primary and secondary oral squamous cell carcinoma: An independent prognostic marker: A retrospective study. J Oral Maxillofac Pathol. 2016;20(2):239–245.
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