Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2019, vol. 56, nr 4, October-December, p. 395–400

doi: 10.17219/dmp/110453

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Effects of the carbonic anhydrase VI gene polymorphisms on dental caries: A meta-analysis

Wpływ polimorfizmów genu anhydrazy węglanowej VI na próchnicę zębów – metaanaliza

Omer Hatipoglu1,A,B,C,D,E,F, Faruk Saydam2,B,E,F

1 Department of Restorative Dentistry, Kahramanmaraş Sütçü İmam University, Turkey

2 Department of Medical Biology, Recep Tayyip Erdoğan University, Rize, Turkey


Background. Carbonic anhydrase VI (CA VI) is considered to greatly participate in the buffering of saliva, ion transport, the regulation of pH, secretory processes, and saliva production. Various studies have been conducted to investigate the relationship between CA VI and dental caries.
Objectives. The goal of this study was to make a meta-analysis of studies that examined the effects of the CA VI gene polymorphisms on dental caries.
Material and Methods. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guide was followed. Electronic databases (PubMed, Web of Science, Scopus, and Cochrane Library) were scanned by 2 independent researchers. The funnel plot, Egger’s regression and Begg and Mazumdar’s rank correlation test were used to determine publication bias. Cohen’s d was used to measure the effect size.
Results. Four studies were included in the meta-analysis; a total of 3 polymorphisms (rs2274327, rs2274328, rs2274333) and a total of 13 polymorphism models were analyzed. According to Egger’s regression and the Begg and Mazumdar’s test, the meta-analysis had no significant publication bias (p > 0.05). The highest susceptibility effect was noticed in the rs2274328 (AA vs CC) model (d = 0.18; 95% CI (confidence interval): −1.77, 2.13), but this effect was not significant (p = 0.237), and the highest protective effect was observed in the rs2274328 (AA vs AC) model (d = −0.13, 95% CI: −1.36, 1.11), but this effect was not significant, either (p = 0.195). No association was found between any of the polymorphism models and dental caries (p > 0.05).
Conclusion. Even though CA VI plays an important role in the buffering of saliva, it was shown that polymorphisms in the CA VI gene did not affect the process of dental caries.

Key words

single-nucleotide polymorphism, meta-analysis, caries susceptibility, dental caries resistance, human genome

Słowa kluczowe

polimorfizm pojedynczego nukleotydu, metaanaliza, podatność na próchnicę, odporność na próchnicę zębów, ludzki genom

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