Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

Download PDF

Dental and Medical Problems

2019, vol. 56, nr 3, July-September, p. 311–316

doi: 10.17219/dmp/109807

Publication type: clinical case

Language: English

Download citation:

  • BIBTEX (JabRef, Mendeley)
  • RIS (Papers, Reference Manager, RefWorks, Zotero)

Creative Commons BY-NC-ND 3.0 Open Access

Transformation of a glandular odontogenic cyst into mucoepidermoid carcinoma of the mandible: A case report

Transformacja zębopochodnej torbieli gruczołowej w raka śluzowo-płaskonabłonkowego żuchwy – opis przypadku

Mateusz Dymek1,2,A,B,C,D,E,F, Mariusz Książek3,C,D,E, Bogumił Lewandowski2,A,E,F

1 Collegium Medicum of the University of Rzeszów, Poland

2 Department of Maxillofacial Surgery, Fryderyk Chopin Clinical Voivodeship Hospital No.1 in Rzeszów, Poland

3 Department of Pathology, MedLifeCover, Krosno, Poland


The glandular odontogenic cyst (GOC) is a rare pathology of odontogenic origin, which can behave unpredictably. It is problematic in clinical, radiographic and histological diagnostics. Intraosseous mucoepidermoid carcinoma (MEC) is a rare tumor which affects the jaws, typically found in the mandible. This malignancy, which usually originates from the salivary glands, can also be caused by a transformation of the mucous cells found in odontogenic cysts. This article presents a rare case of GOC transforming into MEC of the mandible, which was reported during the treatment of a 52-year-old male patient. The aim of this work was to present some of the therapeutic and clinical difficulties encountered when GOC transforms into mucoepidermoid cancer in the mandible, considering the pathomorphological and histological differentiations. The differentiation between MEC and GOC might be difficult through microscopic examination and requires the cooperation of a clinician – a maxillofacial surgeon – and a histopathologist.

Key words

glandular odontogenic cyst, mucoepidermoid carcinoma, neoplastic transformation

Słowa kluczowe

zębopochodna torbiel gruczołowa, rak śluzowo-płaskonabłonkowy, transformacja nowotworowa

References (26)

  1. Abdolsamadi H, Sadr P, Barakian Y. Glandular odontogenic cyst: A case report. Avicenna J Dent Res. 2016;8(1):e25605.
  2. Padayachee A, Van Wyk CW. Two cystic lesions with features of both the botryoid odontogenic cyst and the central mucoepidermoid tumour: Sialo-odontogenic cyst? J Oral Pathol. 1987;16(10):499–504.
  3. Gardner DS, Kessler HP, Morency R, Schaffner DL. The glandular odontogenic cyst: An apparent entity. J Oral Pathol. 1988;17(8):359–366.
  4. Fowler CB, Brannon RB, Kessler HP, Castle JT, Kahn MA. Glandular odontogenic cyst: Analysis of 46 cases with special emphasis on microscopic criteria for diagnosis. Head Neck Pathol. 2011;5(4):364–375.
  5. Kasaboğlu O, Başal Z, Usubütün A. Glandular odontogenic cyst presenting as a dentigerous cyst: A case report. J Oral Maxillofac Surg. 2006;64(4):731–733.
  6. Araújo de Morais HH, José de Holanda Vasconcellos R, de Santana Santos T, Guedes Queiroz LM, Dantas da Silveira ÉJ. Glandular odontogenic cyst: Case report and review of diagnostic criteria. J Craniomaxillofac Surg. 2012;40(2):e46–e55.
  7. Krishnamurthy A, Sherlin HJ, Ramalingam K, et al. Glandular odontogenic cyst: Report of two cases and review literature. Head Neck Pathol. 2009;3(2):153–158.
  8. Kaplan I, Anavi Y, Hirshberg A. Glandular odontogenic cyst: A challenge in diagnosis and treatment. Oral Dis. 2008;14(7):575–581.
  9. Patil AA, Barpande SR, Bhavthankar JD, Mandale MS. Glandular odontogenic cyst presenting as an aggressive multifocal lesion: Case report and review literature. Int J Oral Maxillofac Pathol. 2014;5(2):13–17.
  10. Kaplan I, Anavi Y, Manor R, Sulkes J, Calderon S. The use of mole­cular markers as an aid in the diagnosis of glandular odontogenic cyst. Oral Oncol. 2005;41(9):895–902.
  11. Pires FR, Chen SY, da Cruz Perez DE, de Almeida OP, Kowalski LP. Cytokeratin expression in central mucoepidermoid carcinoma and glandular cyst. Oral Oncol. 2004;40(5):545–551.
  12. de Sousa SO, Cabezas NT, de Oliveira PT, de Araújo VC. Glandular odontogenic cyst: Report of a case with cytokeratin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83(4):478–483.
  13. Vered M, Allon I, Buchner A, Dayan D. Is maspin immunolocalization a tool to differentiate central low-grade mucoepidermoid carcinoma from glandular odontogenic cyst? Acta Histochem. 2010;112(2):161–168.
  14. Khan HA, Loya A, Azhar R, Din NV, Bell D. Central mucoepidermoid carcinoma, a case report with molecular analysis of the TORC1/MAML2 gene fusion. Head Neck Pathol. 2010;4(3):261–264.
  15. Macdonald-Jankowski DS. Glandular odontogenic cyst: Systematic review. Dentomaxillofac Radiol. 2010;39(3):127–139.
  16. Boffano P, Cassarino E, Zavattero E, Campisi P, Garzino-Demo P. Surgical treatment of glandular odontogenic cysts. J Craniofac Surg. 2010;21(3):776–780.
  17. Manojlović S, Grgurević J, Knezević G, Kruslin B. Glandular odontogenic cyst: A case report and clinicopathologic analysis of the relationship to central mucoepidermoid carcinoma. Head Neck. 1997;19(3):227–231.
  18. Prabhu S, Rekha K, Kumar G. Glandular odontogenic cyst mimicking central mucoepidermoid carcinoma. J Oral Maxillofac Pathol. 2010;14(1):12–15.
  19. Eversole LR, Sabes WR, Rovin S. Aggressive growth and neoplastic potential of odontogenic cysts: With special reference to central epidermoid and mucoepidermoid carcinomas. Cancer. 1975;35(1):270–282.
  20. Keszler A, Piloni MJ. Malignant transformation in odontogenic keratocysts. Case report. Med Oral. 2002;7(5):331–335.
  21. Masthan KMK, Rajkumari S, Deepasree M, Aravindha Babu N, Leena Sankari S. Neoplasms associated with odontogenic cysts. J Dent Oral Hyg. 2011;3(10):123–130.
  22. Aggarwal P, Saxena S. Aggressive growth and neoplastic potential of dentigerous cysts with particular reference to central mucoepidermoid carcinoma. Br J Oral Maxillofac Surg. 2011;49(6):e36–e39.
  23. Stoelinga PJ, Bronkhorst FB. The incidence, multiple presentation and recurrence of aggressive cysts of the jaws. J Craniomaxillofac Surg. 1988;16(4):184–195.
  24. Chan KC, Pharoah M, Lee L, Weinreb I, Perez-Ordonez B. Intraosseus mucoepidermoid carcinoma: A review of the diagnostic imaging features of four jaw cases. Dentomaxillofac Radiol. 2013;42(4):20110162.
  25. Mascitti M., Santarelli A, Sabatucci A. Glandular odontogenic cyst: Review of literature and report of a new case with cytokeratin-19 expression. Open Dent J. 2014;8:1–12.
  26. Moghadam SA, Moghadam AF. Intraosseus mucoepidermoid carcinoma: Report of two cases. J Dent (Shiraz). 2014;15(2):86–90.