Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
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ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2019, vol. 56, nr 2, April-June, p. 131–136

doi: 10.17219/dmp/105562

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

In vitro evaluation of the effects of frequently prescribed pediatric drugs on the microhardness of permanent tooth enamel

Ocena in vitro oddziaływań często stosowanych leków pediatrycznych na mikrotwardość szkliwa zębów stałych

Nagehan Yılmaz1,D, Ozgul Baygin1,A, Tugba Nigar Cakıroglu2,B, Tamer Tüzüner1,C, Orhan Deger3,E

1 Department of Pediatric Dentistry, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey

2 Department of Biochemistry, Faculty of Medicine, Avrasya University, Trabzon, Turkey

3 Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey

Abstract

Background. Dental erosion is considered one of the oral cavity diseases. Frequent intake of liquid oral medications can be an effective factor in tooth erosion.
Objectives. This study aimed to evaluate the effects of frequently prescribed pediatric drugs on the permanent dental enamel microhardness over a period of 14 days in vitro.
Material and Methods. In this study, 11 pediatric drugs with different active ingredients were used; the control group consisted of teeth immersed in distilled water. The immersion cycles were applied 3 times a day for 1 min. The measurements of the samples prepared were taken at 0 (baseline), 7 and 14 days after the immersion cycles using a Vickers hardness testing machine. The pH, titratable acidity (TA) and buffering capacity of the syrups were assessed.
Results. The measurements of the tooth samples that were immersed in drug solutions except Deltacortril® showed that there was a significant difference between days 0, 7 and 14. The microhardness values for the tooth samples that were immersed in the Deltacortril drug solution decreased, but no significant difference was found. There were no statistically significant differences between the day 0, 7 and 14 measurements in the control group.
Conclusion. Commonly used and prescribed pediatric drugs pose a risk for tooth erosion. Pediatricians should be aware of the effects of prescription drugs on erosion, and stress the need for compliancy with oral hygiene procedures.

Key words

microhardness, dental erosion, pediatric syrup, permanent dental enamel

Słowa kluczowe

mikrotwardość, erozja zębów, syrop dla dzieci, szkliwo zębów stałych

References (32)

  1. Cavalcanti AL, De Sousa RI, Clementino MA, Vieira FF, Cavalcanti CL, Xavier AF. In vitro analysis of the cariogenic and erosive potential of paediatric antitussive liquid oral medications. Tanzan J Health Res. 2012;14(2):139–145.
  2. Mali GV, Dodamani AS, Karibasappa GN, Kumar PV, Jain VM. Effect of conventional and sugar free pediatric syrup formulations on primary tooth enamel hardness: An in vitro study. J Indian Soc Pedod Prev Dent. 2015;33(4):331–336.
  3. Shellis RP, Featherstone JD, Lussi A. Understanding the chemistry of dental erosion. Monogr Oral Sci. 2014;25:163–179.
  4. Hicks J, Garcia-Godoy F, Flaitz C. Biological factors in dental caries enamel structure and the caries process in the dynamic process of demineralization and remineralization (part 2). J Clin Pediatr Dent. 2004;28(2):119–124.
  5. Zanatta RF, Esper MÂ, Valera MC, Melo RM, Bresciani E. Harmful effect of beer on bovine enamel microhardness – in vitro study. PLoS One. 2016;11(10):e0163440.
  6. Mantonanaki M, Koletsi-Kounari H, Mamai-Homata E, Papaioannou W. Dental erosion prevalence and associated risk indicators among preschool children in Athens, Greece. Clin Oral Investig. 2013;17(2):585–593.
  7. Zero DT. Etiology of dental erosion – extrinsic factors. Eur J Oral Sci. 1996;104(2 (Pt 2)):162–177.
  8. Costa CC, Almeida IC, Costa Filho LC. Erosive effect of an antihistamine-containing syrup on primary enamel and its reduction by fluoride dentifrice. Int J Paediatr Dent. 2006;16(3):174–180.
  9. Maguire A, Baqir W, Nunn JH. Are sugars-free medicines more erosive than sugars-containing medicines? An in vitro study of paediatric medicines with prolonged oral clearance used regularly and long-term by children. Int J Paediatr Dent. 2007;17(4):231–238.
  10. Nunn JH, Ng SK, Sharkey I, Coulthard M. The dental implications of chronic use of acidic medicines in medically compromised children. Pharm World Sci. 2001;23(3):118–119.
  11. Valinoti AC, Neves BG, da Silva EM, Maia LC. Surface degradation of composite resins by acidic medicines and pH-cycling. J Appl Oral Sci. 2008;16(4):257–265.
  12. Scatena C, Galafassi D, Gomes-Silva JM, Borsatto MC, Serra MC. In vitro erosive effect of pediatric medicines on deciduous tooth enamel. Braz Dent J. 2014;25(1):22–27.
  13. Lussi A, Jaeggi T. Erosion – diagnosis and risk factors. Clin Oral Investig. 2008;12(Suppl 1):S5–S13.
  14. Tupalli AR, Satish B, Shetty BR, Battu S, Kumar JP, Nagaraju B. Evaluation of the erosive potential of various pediatric liquid medicaments: An in-vitro study. J Int Oral Health. 2014;6(1):59–65.
  15. Lussi A, Carvalho TS. Erosive tooth wear: A multifactorial condition of growing concern and increasing knowledge. Monogr Oral Sci. 2014;25:1–15.
  16. Addy M, Shellis RP. Interaction between attrition, abrasion and erosion in tooth wear. Monogr Oral Sci. 2006;20:17–31.
  17. Nunn JH, Gordon PH, Morris AJ, Pine CM, Walker A. Dental erosion – changing prevalence? A review of British National childrens’ surveys. Int J Paediatr Dent. 2003;13(2):98–105.
  18. Carvalho TS, Lussi A, Jaeggi T, Gambon DL. Erosive tooth wear in children. Monogr Oral Sci. 2004;25:262–278.
  19. Valinoti AC, Pierro VS, Da Silva EM, Maia LC. In vitro alterations in dental enamel exposed to acidic medicines. Int J Paediatr Dent. 2011;21(2):141–150.
  20. Yesilyurt C, Sezer U, Ayar MK, Alp CK, Tasdemir T. The effect of a new calcium-based agent, Pro-Argin, on the microhardness of bleached enamel surface. Aust Dent J. 2013;58(2):207–212.
  21. McKnight-Hanes C, Whitford GM. Fluoride release from three glass ionomer materials and the effects of varnishing with or without finishing. Caries Res. 1992;26(5):345–350.
  22. Amaechi BT, Higham SM, Edgar WM. Factors influencing the development of dental erosion in vitro: Enamel type, temperature and exposure time. J Oral Rehabil. 1999;26(8):624–630.
  23. Dhawan L, Geetanjali, Narang A, Gill GS, Toor JS, Sandhu SS. In-vitro study for comparative analysis of erosive potential of pediatric liquid medicinal syrups on deciduous teeth. Int J Com Health Med Res. 2017;3(2):92–95.
  24. Kulkarni P, Anand A, Bansal A, Jain A, Tiwari U, Agrawal S. Erosive effects of pediatric liquid medicinal syrups on primary enamel: An in vitro comparative study. Indian J Dent. 2016;7(3):131–133.
  25. Kaur M, Bhaskar V, Ganesh M, Joshi K, Trivedı K. Comparative evaluation of the erosive potential of commonly used beverages and medicated syrup – an in vitro study. J Ahmedabad Dent Coll Hosp. 2012;3(1):19–25.
  26. Hellwig E, Lussi A. Oral hygiene products, medications and drugs – hidden aetiological factors for dental erosion. Monogr Oral Sci. 2014;25:155–162.
  27. Tahmassebi JF, Duggal MS, Malik-Kotru G, Curzon ME. Soft drinks and dental health: A review of the current literature. J Dent. 2006;34(1):2–11.
  28. Hara AT, Ando M, González-Cabezas C, Cury JA, Serra MC, Zero DT. Protective effect of the dental pellicle against erosive challenges in situ. J Dent Res. 2006;85(7):612–616.
  29. Dugmore CR, Rock WP. Asthma and tooth erosion. Is there an association? Int J Paediatr Dent. 2003;13(6):417–424.
  30. Al-Dlaigan YH, Shaw L, Smith AJ. Is there a relationship between asthma and dental erosion? A case control study. Int J Paediatr Dent. 2002;12(3):189–200.
  31. Xavier AF, Moura EF, Azevedo WF, Vieira FF, Abreu MH, Cavalcanti AL. Erosive and cariogenicity potential of pediatric drugs: Study of physicochemical parameters. BMC Oral Health. 2013;13:71.
  32. Pasdar N, Alaghehmand H, Mottaghi F, Tavassoli M. Experimental study of iron and multivitamin drops on enamel microhardness of primary tooth. J Int Soc Prev Community Dent. 2015;5(6):518–524.
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