Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2019, vol. 56, nr 2, April-June, p. 131–136

doi: 10.17219/dmp/105562

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

In vitro evaluation of the effects of frequently prescribed pediatric drugs on the microhardness of permanent tooth enamel

Ocena in vitro oddziaływań często stosowanych leków pediatrycznych na mikrotwardość szkliwa zębów stałych

Nagehan Yılmaz1,D, Ozgul Baygin1,A, Tugba Nigar Cakıroglu2,B, Tamer Tüzüner1,C, Orhan Deger3,E

1 Department of Pediatric Dentistry, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey

2 Department of Biochemistry, Faculty of Medicine, Avrasya University, Trabzon, Turkey

3 Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey


Background. Dental erosion is considered one of the oral cavity diseases. Frequent intake of liquid oral medications can be an effective factor in tooth erosion.
Objectives. This study aimed to evaluate the effects of frequently prescribed pediatric drugs on the permanent dental enamel microhardness over a period of 14 days in vitro.
Material and Methods. In this study, 11 pediatric drugs with different active ingredients were used; the control group consisted of teeth immersed in distilled water. The immersion cycles were applied 3 times a day for 1 min. The measurements of the samples prepared were taken at 0 (baseline), 7 and 14 days after the immersion cycles using a Vickers hardness testing machine. The pH, titratable acidity (TA) and buffering capacity of the syrups were assessed.
Results. The measurements of the tooth samples that were immersed in drug solutions except Deltacortril® showed that there was a significant difference between days 0, 7 and 14. The microhardness values for the tooth samples that were immersed in the Deltacortril drug solution decreased, but no significant difference was found. There were no statistically significant differences between the day 0, 7 and 14 measurements in the control group.
Conclusion. Commonly used and prescribed pediatric drugs pose a risk for tooth erosion. Pediatricians should be aware of the effects of prescription drugs on erosion, and stress the need for compliancy with oral hygiene procedures.

Key words

microhardness, dental erosion, pediatric syrup, permanent dental enamel

Słowa kluczowe

mikrotwardość, erozja zębów, syrop dla dzieci, szkliwo zębów stałych

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