Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2020) – 128.41
MEiN – 70 pts
CiteScore (2021) – 2.0
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Average rejection rate (2021) – 81.35%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2019, vol. 56, nr 1, January-March, p. 75–80

doi: 10.17219/dmp/100444

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Effect of acute methyl methacrylate vapor inhalation on smokers’ and non-smokers’ respiratory function in a sample of male dentistry students

Wpływ wdychania znacznych ilości oparów metakrylanu metylu na funkcje oddechowe osób palących i niepalących – na przykładzie studentów stomatologii płci męskiej

Malath Azeez Al-Saadi1,A,B,C,D,E,F, Anas Al-Yasiry1,A,B,E,F, Zainab Al-Jammali2,B,E,F, Aoss Moez1,B,F

1 Department of Basic Science, Faculty of Dentistry, University of Babylon, Hilla, Iraq

2 Department of Prosthodontics, Faculty of Dentistry, University of Babylon, Hilla, Iraq

Abstract

Background. Methyl methacrylate (MMA) is one of the widely used organic monomers in dentistry. It may cause multiple adverse reactions, ranging from allergic reaction to systemic toxicity. Dentistry students are exposed to MMA in an acute manner; however, the concentration of its vapor cannot be estimated well.
Objectives. The aim of this study was to evaluate the effect of acute MMA vapor inhalation on the pulmonary function of dental students, both smokers and non-smokers.
Material and Methods. Thirty-eight male dental students were divided into 2 groups (group 1 – smokers and group 2 – non-smokers). The lung function parameters of the students were tested with a spirometer during their ordinary training work in a prosthodontics laboratory, before contact with MMA and immediately after it. The lung function test was performed using a standard protocol. The students were asked not to use any perfume or aromatic overlaps for a period of 24 h before starting the tests.
Results. The researchers noted a statistically significant decrease (p ≤ 0.05) in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75), and forced expiratory flow at 25% (FEF25) and 50% (FEF50) of the pulmonary volume in smokers and non-smokers by comparing the preand post-work tests.
Conclusion. Acute inhalation of MMA vapor induced a moderate restriction of pulmonary function in dental students, both smokers and non-smokers, during their routine prosthodontics laboratory training work. No differences in the results of the pulmonary function tests between smokers and non-smokers were observed.

Key words

spirometer, pulmonary function, smokers, methyl methacrylate

Słowa kluczowe

spirometr, funkcjonowanie płuc, osoby palące, metakrylan metylu

References (25)

  1. Aalto-Korte K, Alanko K, Kuuliala O, Jolanki R. Methacrylate and acrylate allergy in dental personnel. Contact Dermatitis. 2007;57(5):324–330.
  2. Pohanish RP. Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens. Vol. 1. Norwich, NY: Noyes/William Andrews Publishing; 2002:1595.
  3. Chan PC, Eustis SL, Huff JE, Haseman JK, Ragan H. Two-year inhalation carcinogenesis studies of methyl methacrylate in rats and mice: Inflammation and degeneration of nasal epithelium. Toxicology. 1988;52(3):237– 252.
  4. Sasseville D. Acrylates in contact dermatitis. Dermatitis. 2012;23(1):6–16.
  5. Blanchet LJ, Bowman MS, McReynolds HD. Effects of methyl methacrylate monomer vapors on respiration and circulation in unanesthetized rats. J Prosthet Dent. 1982;48(3):344–347.
  6. Brüning T, Bartsch R, Bolt HM, et al. Sensory irritation as a basis for setting occupational exposure limits. Arch Toxicol. 2014;88(10):1855–1879.
  7. Gautam R, Singh RD, Sharma VP, Siddhartha R, Chand P, Kumar R. Biocompatibility of polymethylmethacrylate resins used in dentistry. J Biomed Mater Res B Appl Biomater. 2012;100(B):1444–1450.
  8. Lyapina M, Dencheva M, Krasteva A, Tzekova M, Kisselova-Yaneva A. Concomitant contact allergy to formaldehyde and methacrylic monomers in students of dental medicine and dental patients. Int J Occup Med Environ Health. 2014;27(5):797–807.
  9. Rashid H, Sheikh Z, Vohra F. Allergic effects of the residual monomer used in denture base acrylic resins. Eur J Dent. 2015;9(4):614–619.
  10. Walther UI, Walther SC, Liebl B, et al. Cytotoxicity of ingredients of various dental materials and related compounds in L2- and A549 cells. J Biomed Mater Res. 2002;63(5):643–649.
  11. Sokmen S, Oktemer M. Histopathological examinations of rat lungs that exposed to low concentration of methyl methacrylate monomer vapor. J Hacettepe Fac Dent. 1988;12:1–4.
  12. Ferrer E, Peinado VI, Díez M, et al. Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig. Respir Res. 2009;10:76.
  13. Urrutia I, Capelastegui A, Quintana JM, Muñiozguren N, Basagana X, Sunyer J; Spanish Group of the European Community Respiratory Health Survey (ECRHS-I). Smoking habit, respiratory symptoms and lung function in young adults. Eur J Public Health. 2005;15(2):160–165.
  14. Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality: A population-based study and a systematic review of the literature. Chest. 2005;127(6):1952–1959.
  15. Mannino DM, Holguin F, Pavlin BI, Ferdinands JM. Risk factors for prevalence of and mortality related to restriction on spirometry: Findings from the First National Health and Nutrition Examination Survey and follow-up. Int J Tuberc Lung Dis. 2005;9(6):613–621.
  16. Al-Yasiry A, Al-Jammali ZM, Almuthaffer A, Moez A. Effect of monomer inhalation on the lung function volume of dentistry female students by using the spirometer. Med J Babylon. 2017;14(2):300–308.
  17. Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–968.
  18. Gosavi SS, Gosavi SY, Alla RK. Local and systemic effects of unpolymerised monomers. Dent Res J (Isfahan). 2010;7(2):82–87.
  19. Lyapina М, Dencheva M, Krasteva A, et al. Health risk assessment in exposure to methacrylic monomers in dental practice. J Sci Res Rep. 2014;3(22):2848–2863.
  20. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159(1):179–187.
  21. Miller K, Chang A. Acute inhalation injury. Emerg Med Clin North Am. 2003;21(2):533–535.
  22. Kenfield SA, Wei EK, Rosner BA, Glynn RJ, Stampfer MJ, Colditz GA. Burden of smoking on cause-specific mortality: Application to the Nurses’ Health Study. Tob Control. 2010;19(3):248–254.
  23. Marez T, Edmé JL, Bulenguez C, Shirali P, Haguenoer JM. Bronchial symptoms and respiratory function in workers exposed to methylmethacrylate. Br J Ind Med. 1993;50(10):894–897.
  24. Borak J, Fields C, Andrews LS, Pemberton MA. Methyl methacrylate and respiratory sensitization: A critical review. Crit Rev Toxicol. 2011;41(3):230–268.
  25. Gorguner M, Akgun M. Acute inhalation injury. Eurasian J Med. 2010;42(1):28–35.