Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2020) – 128.41
MEiN – 70 pts
CiteScore (2021) – 2.0
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ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2018, vol. 55, nr 3, July-September, p. 343–349

doi: 10.17219/dmp/95028

Publication type: clinical case

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Microdontia after chemotherapy in a patient treated for neuroblastoma: Histopathological findings

Mikrodoncja po chemioterapii u pacjenta leczonego z powodu nerwiaka zarodkowego – badania histopatologiczne

Anna Jodłowska1,A,B,C,D, Jacek Pająk2,B,C,E, Lidia Postek-Stefańska1,E,F

1 Department of Pediatric Dentistry, Medical University of Silesia, Katowice, Poland

2 Department of Patomorphology and Molecular Diagnostics, Medical University of Silesia, Katowice, Poland

Abstract

Microdontia is one of the late effects of antineoplastic therapy in children. This study is based on the comparative histological examination of abnormal, peg-shaped premolars, erupted in a patient treated for neuroblastoma, and of non-affected teeth, extracted in a healthy child. Apart from the size, the teeth vary in tissue morphology. The number of dentinal tubules, dependent on the number of odontoblasts, is smaller in the microdontal sample when observation in the same-sized field of view is conducted. Moreover, the youngest, more than 100-micrometer-thick layer of the microdontal dentin seems to be the secondary dentin, with crispy-shaped tubules and empty spaces between them. No irregular dentin is deposited in the samples of physiologically developed teeth. The structure of cementum is different as well. Unlike regularly shaped premolars, in which typical 2-layer tissue is seen, in sections of microdontal teeth, only acellular tissue with cementoblasts overlying its surface is present. Thorough analysis of drug administration effects, which are visible in microscopic sections, and of time of anticancer treatment could provide insight into the developmental mechanisms of tooth germ formation.

Key words

chemotherapy, histopathology, tooth abnormalities, neuroblastoma

Słowa kluczowe

chemioterapia, histopatologia, zaburzenia zębowe, nerwiak zarodkowy

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