Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2020) – 128.41
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI – 0.5
Average rejection rate (2021) – 81.35%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2018, vol. 55, nr 1, January-March, p. 75–82

doi: 10.17219/dmp/81259

Publication type: review article

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Helicobacter pylori w jamie ustnej – interakcje z mikrobiotą gospodarza

Paweł Krzyżek1,A,B,C,D,F, Grażyna Gościniak1,E,F

1 Department of Microbiology, Wroclaw Medical University, Poland

Abstract

The role of the oral cavity as a reservoir for Helicobacter pylori is still a controversial issue. There is a great number of articles indicating the presence of this pathogen in the oral cavity, but discrepancies among techniques for H. pylori detection and the variations in the patients tested often make it difficult to formulate a final verdict. Outer membrane proteins (OMPs) are one of the most important factors determining colonization of H. pylori in the oral cavity. Among them, the key role is attributed to BabA, SabA and NapA, all of which promote adherence and retention within this area. The oral cavity is characterized by the co-existence of numerous microorganisms which may potentially affect the physiology and morphology of H. pylori. The presence of coccoid-stimulating factors and relatively low levels of AI-2 in the earlyto mid-stages of supragingival plaque allow dental H. pylori to colonize this niche as nonculturable spherical forms. On the other hand, subgingival plaque characterized by high numbers of periopathogens, capable of synthesizing high concentrations of AI-2, may favor the presence of mixed populations of spiral and coccoid H. pylori forms. This review article provides an up-to-date knowledge about the ability of oral H. pylori to interact both with the host and the local microflora of the oral cavity.

Key words

biofilm, Helicobacter pylori, oral cavity, dental plaque, microflora

Słowa kluczowe

biofilm, Helicobacter pylori, jama ustna, płytka nazębna, mikroflora

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