Dental and Medical Problems

Dent Med Probl
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ISSN 1644-387X (print)
ISSN 2300-9020 (online)
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Dental and Medical Problems

2017, vol. 54, nr 3, July-September, p. 273–278

doi: 10.17219/dmp/75796

Publication type: review article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Odontostomatological manifestations in sickle cell disease: A systematic review

Objawy stomatologiczne w niedokrwistości sierpowatej – przegląd systematyczny

Gianfilippo Nifosi1,A,B,C,D,F, Antonio Fabrizio Nifosi2,B,D,E,F, Lorenzo Nifosi3,B,D,E,F

1 CHU Brugmann, Bruxelles, Belgium

2 Dental Clinic iDental, Valencia, Spain

3 European University of Valencia, Valencia, Spain


Sickle-cell disease is a frequent hemoglobinopathy which represents a major public health problem as a result of the continuous migration of populations. The clinical manifestations are chronic hemolytic anemia, vaso-occlusive crisis and infections; however, the involvement of the head and neck region remains poorly reported. Particularly, we do not know the prevalence of the odontostomatological manifestations. In this study, we reviewed the most recent literature on the topic. We have classified the alterations of the orofacial sphere into four categories: oral manifestations, bone changes, infections and various. We have described the main clinical manifestations of each one, along with their incidence and prevalence, trying to identify the pathophysiological mechanisms, correlations with vaso-occlusive crisis and possible therapeutic strategies. Several odontostomatological manifestations are described in patients with sickle cell disease. Some are typical, while others still need to be investigated, as for example the relationship between oral triggers and vaso-occlusive crisis.

Key words

sickle cell anemia, bone marrow hyperplasia, orofacial alterations

Słowa kluczowe

niedokrwistość sierpowata, rozrost szpiku kostnego, zmiany w jamie ustnej

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