Dental and Medical Problems

Dent Med Probl
Impact Factor (IF 2023) – 2.7
Journal Citation Indicator (JCI 2023) - 1.06
Scopus CiteScore (2023) – 4.0 (CiteScore Tracker – 4.9)
Index Copernicus (ICV 2023) – 181.00
MNiSW – 70 pts
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – bimonthly


 

Download original text (EN)

Dental and Medical Problems

2017, vol. 54, nr 2, April-June, p. 183–187

doi: 10.17219/dmp/68604

Publication type: review

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

Download citation:

  • BIBTEX (JabRef, Mendeley)
  • RIS (Papers, Reference Manager, RefWorks, Zotero)

The algorithm of dental treatment in patients before and after organ transplantation

Schemat postępowania stomatologicznego przed transplantacją narządową i po niej

Dorota Szubińska-Lelonkiewicz1,A,C,D,E, Magdalena Golecka-Bąkowska2,A,C,D, Martyna Osiak1,A,B,F

1 Dental Surgery Department, Medical University of Warsaw, Warszawa, Poland

2 Department of Prosthodontics, Medical University of Warsaw, Warszawa, Poland

Abstract

The vascularized organs transplantation has become an effective method of treating patients with end-stage organ failure. However, prolonged immunosuppressive therapy causes many side effects, which are reflected in the state of the oral cavity. Infections in transplant recipients represent the most common postoperative complication. The development of infection is dependent on pathogenic microorganisms as bacteria, fungi and viruses, including CMV, EBV, HPV, HIV. To reduce the potential for serious problems in the oral cavity occurring after organ transplantation, each patient should be subjected to a thorough dental inspection and treated by physicians in specialized medical centers. The role of a dentist should involve the evaluation before and after transplantation according to specialized algorithm of dental treatment. The information concerning the presence of infection outbreaks and pathologic lesions in the oral cavity is an important signal for transplant physician to perform extended diagnostic testing, as well as to modify the immunosuppressive therapy.

Key words

oral cavity, viral infections, dental treatment, transplant recipients, organ transplantations

Słowa kluczowe

jamy ustna, zakażenia wirusowe, leczenie stomatologiczne, biorcy przeszczepów, transplantacja narządów

References (31)

  1. Durlik M. Cancers in kidney transplant recipients – role of viral infections and immunosuppressive drugs. Post Nauk Med. 2009;10:827–833.
  2. Smith SR, Butterly DW, Alexander BD, Greenberg A. Viral infection after transplantation. Am J Kidney Dis. 2001;37:659–676.
  3. Wróblewska M, Swoboda-Kopeć E, Kawecki D, Łuczak M. Infections as a potential complication factor in patients with diabetes and transplantation. Med Dydak Wychow. 2004;36:38–43 (in Polish).
  4. Chomicz L, Piekarczyk J, Fiedor P. Comparative studies on the occurence of protozoans, bacteria and fungi in the oral cavity of patients with systemic disorders. Acta Parasitol Pol. 2002;47:147–153 (in Polish).
  5. Baranowicz-Gąszczyk I, Jóźwiak L, Sykut J, Jaroszewicz E, Książek A. Dental and prosthetic status of hemodialyzed patients. Reason of prosthetic treatment restriction. Nefrol Dial Pol. 2008;12:171–175 (in Polish).
  6. Łabij-Reduta B, Żółtko J, Borawski J, Naumnik B. Oral dryness in chronic hemodialysis patients – importance, diagnosis and treatment. Nefrol Dial Pol. 2015;19:50–54.
  7. Rasławska J, Dembowska E. Chronic kidney disease and dialysis and oral health. Dent Med Probl. 2011;48:405–411 (in Polish).
  8. Sokołowska-Trelka A, Grzebieluch W, Dubiński B. Specific dental problems of end-stage renal disease patients. Dent Med Probl. 2005;42:351–355 (in Polish).
  9. Szyszkowska A, Jachewicz T. Oral cavity sanitation as a preparation to vascularized organs transplantation and bone marrow. Implantoprot. 2009;3:35–39 (in Polish).
  10. Olczak-Kowalczyk D, Podymiak-Wojciechowska M, Pawłowska J, Durdyń M, Grenda R. Changes in the oral cavity and treatment problems in children on pharmacological immunosuppression following organ transplantation (the authors experience). Czas Stomatol. 2003;56:529–534 (in Polish).
  11. Szubińska D, Golecka-Bąkowska M. Preventive dentistry. Principles of oral hygiene. Liver transplantation. Nowe życie. Poradnik dla pacjentów. 2012;8:109–110 (in Polish).
  12. Chomicz L, Piekarczyk J, Fiedor P, et al. Screening evaluation of oral cavity microorganisms in dialyzed and kidney allograft recipients under chronic immunosuppression. Transplant Proc. 2002;34:675–676.
  13. Olczak-Kowalczyk D, Pawłowska J, Śmirska E, Grenda R. Pathological changes in oral cavity in cytomegalovirus (CMV) infection in organ transplant recipients – the author’s experience. Czas Stomatol. 2004;57:695–699 (in Polish).
  14. Ammatuna P, Campisi G, Giovanelli L, et al. Presence of Epstein-Barr virus, cytomegalovirus and human papillomavirus in normal oral mucosa of HIV-infected and renal transplant patients. Oral Dis. 2001;7:34–40.
  15. Lima RB, Santos PSS, Malafronte P, Muller H, Caiaffa-Filho HH, Sens YAS. Oral manifestation of cytomegalovirus associated with herpes simplex virus in renal transplant recipient. Transplant Proc. 2008;40:1378–1381.
  16. Chen R, Aaltonen L-M, Vaheri A. Human papillomavirus type 16 in head and neck carcinogenesis. Rev Med Virol. 2005;15:351–363.
  17. Ciechowicz K, Fiedor P, Grabowska K, Duszek M, Wojtowicz A. Histopathological evaluation of the oral mucosa in patients after renal transplantation and with HPV infection. Nowa Stomatol. 2002;7,1:19–24 (in Polish).
  18. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systemic review. Cancer Epdemiol Biomarkers Prev. 2005;14:467–475.
  19. Rose B, Wilkins D, Li W, Tran N, Thompson C. Human papillomavirus in the oral cavity of patients with and without renal transplantation. Transplant. 2006;82:570–573.
  20. Garcia E, Padilla A, Camacho M, Ramirez M. Oral lesions in a group of kidney transplant patients. Med Oral Patol Oral Cir Bucal. 2005;46:196–204.
  21. Chełstowska M, Banach J. Oral candidiasis in renal transplant recipients medicated with Cyclosporin A and Tacrolimus. Dent Med Probl. 2004;41:671–674 (in Polish).
  22. Guggenheimer J, Eghtesad B, Close JM, Shay Ch, Fung JJ. Dental health status of liver transplant candidates. Liver Transplant. 2007;13:280–286.
  23. Golecka M, Ołdakowska-Jedynak U, Mierzwińska-Nastalska E, Adamczyk-Sosińska E. Candida-associated denture stomatitis in patients after immunosuppression therapy. Transplant Proc. 2006;38:155–156.
  24. Bustos DA, Grenon MS, Benitez M, Boccardo G, Pavan JV, Gendelman H. Human papillomavirus infection in Cyclosporin – induced gingival overgrowth in renal allograft recipients. J Periodontol. 2001;72:741–744.
  25. Charazińska-Carewicz K, Czerniuk M, Nowak M. Applications of certain immunosuppressive drugs and the effect on the oral mucosa. Czas Stomatol. 1998;51:650–652 (in Polish).
  26. Radwan-Oczko M, Boratyńska M, Klinger M, Ziętek M. Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A. Ann Transplant. 2003;8,57–62.
  27. Cota LO, Aquino DR, Cortelli JR, Cortelli SC, Costa FO. Gingival overgrowth in subjects under immunosuppressive regiments based on cyclosporine, tacrolimus or sirolimus. J Clin Periodontol. 2010;37:894–902.
  28. Bogusławska-Kapała A, Balon J, Cackowska-Lass A, Hellmann A, Kochańska B. Pathological changes in the oral cavity in bone marrow transplant recipients: On the basis of literature. Czas Stomatol. 2004;56:706–713 (in Polish).
  29. Ujpal M, Matos O, Bibok G, Somogi A, Szabo G, Suba Z. Diabetes and oral tumors in Hungary. Diab Care. 2004;27:770.
  30. Vajdic CM, McDonald SP, McCredie MRE, Chapman JR. Cancer incidence before and after kidney transplantation. JAMA. 2006;296:2823–2831.
  31. Wong G, Chapman JR. Cancer after renal transplantation. Transplant Rev. 2008;22:141–149.
© Wroclaw Medical University