Dental and Medical Problems

Dent Med Probl
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Dental and Medical Problems

2017, vol. 54, nr 1, January-March, p. 67–71

doi: 10.17219/dmp/65450

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Oral hygiene in children with epilepsy: Effect of interleukin-1β and VEGF levels in gingival crevicular fluid

Higiena jamy ustnej dzieci chorych na epilepsję a stężenie interleukiny 1β i czynnika wzrostu naczyniowo-śródbłonkowego w płynie dziąsłowym

Gülsüm Duruk1,A,B,C,D,E,F, Hulya Aksoy2,A,B,C,D, Taskın Gurbuz3,A,B,C, Esra Laloglu4,A,B, Huseyin Tan5,A,B

1 Inonu University, Faculty of Dentistry, Department of Pediatric Dentistry, Malatya, Turkey

2 Private Medical Practice, Erzurum, Turkey

3 Ataturk University, Faculty of Dentistry, Department of Pediatric Dentistry, Erzurum, Turkey

4 Ataturk University, Faculty of Medicine, Department of Biochemistry, Erzurum, Turkey

5 Ataturk University, Faculty of Medicine, Department of Pediatric Neurology, Erzurum, Turkey


Background. The biochemical parameters in gingival crevicular fluid (GCF) are affected by some systemic diseases and poor oral hygiene.
Objectives. The aim of this study was to evaluate the total amounts of Interleukin-1β (IL-1β) and vascular endothelial growth factor (VEGF) in GCF in children with epilepsy.
Material and Methods. Eighty children with epilepsy in a seizure-free period (the test group) and 80 healthy children (the control group) were evaluated. The children with epilepsy were taking valproic acid (VPA), carbamazepine, phenobarbital, and the combinations of these drugs. Gingival index (GI), plaque index (PI), probing depth (PD) and clinical attachment level (CAL) were measured. GCF was collected and its volume was measured. The total amounts of IL-1β and VEGF in the GCF were analyzed in the Biochemistry Laboratory at Ataturk University.
Results. The biochemical (IL-1β and VEGF) and clinical parameters (GI, PI, PD and GCF volume) were significantly higher in children with epilepsy compared to healthy children (p < 0.0001). When the epilepsy patients were divided into groups according to the drug used in this study, there were no significant differences in the GCF levels of IL-1β and VEGF among the drug groups. Also, a significant gingival enlargement in the patient population was not recorded.
Conclusion. According to these results, it may be suggested that patients need optimal oral care in epilepsy.

Key words

children, epilepsy, cytokine, gingival crevicular fluid, oral health

Słowa kluczowe

dzieci, epilepsja, cytokiny, płyn dziąsłowy, higiena jamy ustnej

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