Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2015, vol. 52, nr 4, October-December, p. 472–478

doi: 10.17219/dmp/59557

Publication type: review article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Recurrent Aphthous Stomatitis – a Reflection of Gastrointestinal Diseases?

Afty nawracające jako objaw chorób przewodu pokarmowego

Natalia Lewkowicz1,

1 Department of General Dentistry, Medical University of Lodz, Łódz, Poland


Recurrent oral ulceration is a common condition accompanied by pain which often interferes with food intake and speaking. A variety of etiological factors can contribute to oral ulceration, e.g. local factors, such as trauma or viral infection, or systemic diseases that manifest in the oral cavity. Recurrent aphthous stomatitis (RAS) is one of the most frequently diagnosed condition characterized by repeated appearance of oral ulcers. Clinical features of RAS are not homogenous (different ulcer types, different severity of the disease), and the etiology is unclear. No objective criteria are known for definitive RAS diagnosis, and descriptive criteria are not well-defined. The majority of RAS cases are believed to be idiopathic, but some can be associated with an underlying systemic diseases, including nutritional deficiencies and inflammatory conditions. RAS is relatively often described to be associated with inflammatory diseases of gastrointestinal tract, and sometimes oral manifestation precedes gastrointestinal symptoms.Therefore, dentists might help to diagnose a range of systemic diseases. In the present review, the literature on most commonly RAS-associated conditions, inflammatory diseases associated with gastrointestinal tract, has been analyzed, providing practical tips helping to differentiate between idiopathic RAS and RAS accompanying systemic disease, and to facilitate adequate ulcer management.

Key words

gastrointestinal diseases, recurrent aphthous stomatitis, oral ulcers

Słowa kluczowe

afty nawracające, zamiany nadżerkowe i owrzodzenia jamy ustnej, choroby przewodu pokarmowego

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