Dental and Medical Problems
2015, vol. 52, nr 3, July-September, p. 363–365
Publication type: clinical case
Severe Pigmentation of Oral Mucosa, Skin and Nails Due to Breast Cancer Chemotherapy – Case Report
Nasilone zmiany pigmentowe jamy ustnej, skóry i paznokci w następstwie chemioterapii raka piersi – opis przypadku
1 Department of Oral and Maxillofacial Medicine, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Almost 10–20% of acquired melanocytic pigmentations are drug-induced in origin. Oral mucosa is a common place to develop drug reactions. In a 57-year-old Iranian female, severe pigmentation due to breast cancer chemotherapy with cyclophosphamide, 5-fluorouracil (5-FU) and doxorubicin was noticed during clinical examination. Extra-oral examination revealed linear dark bands on fingerand toenails as well as freckles on the face. Intraoral examination showed asymptomatic diffuse dark-brown pigmentation of the oral mucosa on the tongue, lips, palate, and buccal mucosa. The lesions were of poorly defined borders, various sizes and shape and a heterogeneous coloring to some extent. The tongue was more severely pigmented by dark gray to black patches. The patient was reassured about the etiology and nature of her problem and advised to return two months later. The lesions had almost disappeared by then. Awareness of chemotherapy complications is mandatory for physicians and dental practitioners to make accurate diagnoses.
breast cancer, chemotherapy, pigmentation, oral, skin, nails
rak piersi, chemioterapia, zmiany pigmentowe, jama ustna, skóra, paznokcie
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