Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2015, vol. 52, nr 3, July-September, p. 356–362

Publication type: clinical case

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Dental Abnormalities in a Patient Treated for Neuroblastoma

Zaburzenia rozwojowe uzębienia u pacjenta leczonego z powodu rozpoznania nerwiaka zarodkowego

Anna Jodłowska1,A,B,C,D, Michał Tarnawski2,B,C, Lidia Postek-Stefańska1,E,F

1 Department of Pediatric Dentistry, Medical University of Silesia in Katowice, Zabrze, Poland

2 Private Practice, Katowice, Poland


Long-term cancer survivors require additional diagnostics and care due to the late effects of the neoplasm and its treatment. The type and intensity of the dental pathological changes can be determined among others by the type and dose of the cytostatic drug applied as well as the duration of oncological treatment. Most abnormalities occur in the period of intense development of tooth buds, i.e. before 5 years of age. Neuroblastoma is a solid tumor arising from neural crest cells. It occurs most often in the retroperitoneum and is diagnosed very early, at approximately 2–3 years of age. Chemotherapy administered at that stage of life may subsequently affect dental development. This paper presents a case report of a 13-year-old male patient with microdontia of the four first premolars. The patient was treated with long-term chemotherapy at the time of the first premolar crowns’ development. The treatment of neuroblastoma probably caused these adverse effects. Moreover, clinical examination has revealed enamel anatomical abnormalities of the permanent incisors, canines and first molars.

Key words

neuroblastoma, chemotherapy, dental abnormalities, microdontia, late effects

Słowa kluczowe

nerwiak zarodkowy, chemioterapia, zaburzenia zębowe, mikrodoncja, późne następstwa

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