Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2020) – 128.41
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI – 0.5
Average rejection rate (2021) – 81.35%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2015, vol. 52, nr 3, July-September, p. 265–268

Publication type: editorial article

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Comparative Analysis and Mutual Relations Between Mariginal Periodontitis and Periapical Lesions – Literature Review

Charakterystyka porównawcza i wzajemne relacje między brzeżnym i okołowierzchołkowym zapaleniem przyzębia – przegląd piśmiennictwa

Marek Ziętek1,A,E,F, Izabella Skrzypczyk2,B,C,D, Małgorzata Szulc1,B,C,D

1 Department of Periodontology, Wroclaw Medical University, Wroclaw, Poland

2 Private Practice, Wroclaw, Poland


An analysis is presented of the relation between cases of low and medium advanced periodontitis and apical periodontitis. The systemic and local effects of the above are discussed. Both phenomena are caused by bacterial infections; therefore, inflammation is a predominant symptom. Oxidative stress occurring in these cases recedes after treatment. In the case of apical periodontitis, the correlation between the reduction of oxidative stress markers in serum and endodontic treatment is visible after 90 days. Polymicrobial synergy is very important in the context of connections between apical periodontitis and chronic periodontitis. Cooperation between particular bacteria species significantly increases their virulency. Porphyromonas gingivalis and Filifactor alocis are examples of such cooperation, as are Aggregatibacter actinomycetemcomitans and Streptococcus gordoni. Pathways of communication between the dental pulp and periodontal tissues are known; however, cases of their infection (even in advanced stages of periodontitis) are rare. The complicated structure of the dental pulp and its abilities for regeneration and repair might be of key importance in treating combined periodontic-endodontic lesions.

Key words

oxidative stress, apical periodontitis, marginal periodontitis, polymicrobial synergy

Słowa kluczowe

stres oksydacyjny, zapalenie przyzębia okołowierzchołkowego, zapalenie przyzębia brzeżnego, synergia polibakteryjna

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