Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2021) – 132.50
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI (2021) – 0.5
Average rejection rate (2022) – 79.69%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2015, vol. 52, nr 2, April-June, p. 241–245

Publication type: clinical case

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Severe Oral Lichen Planus Responsive to Topical Cyclosporine A – Case Report

Ciężka postać liszaja płaskiego wrażliwego na miejscowe leczenie cyklosporyną A – opis przypadku

Ewa Krawiecka1,B,C,D, Elżbieta Szponar1,A,E, Barbara Dorocka-Bobkowska2,E,F

1 Department of Oral Mucosa Diseases, Poznań University of Medical Sciences, Poznań, Poland

2 Department of Prosthetic Dentistry, Poznań University of Medical Sciences, Poznań, Poland


Oral lichen planus (OLP) is a chronic, inflammatory, mucocutaneous disease of an autoimmune origin. The disorder may be painful and debilitating and complete resolution is rarely observed. Although there are controversies in the management of symptomatic OLP, topical steroids are considered to be the first line of treatment. Topical cyclosporine (CS) therapy has shown conflicting results in many studies. This paper presents the case of a 70-yearold female patient with a history of hypertension, hypothyroidism and erosive OLP presented with a chief complaint of severe pain and burning sensation on the palate. The patient used acrylic removable partial dentures. OLP was resistant to standard treatment with topical steroids, but responded well to topical CS. Topical administration of the CS solution (“swish-and-spit” method) resulted in marked improvement in the degree of erythema, pain and discomfort. The follow-up showed longer remissions and milder lesions than prior to the therapy and no adverse systemic reactions.

Key words

oral cavity, lichen planus, cyclosporine, steroids

Słowa kluczowe

jama ustna, liszaj płaski, cyklosporyna, steroidy

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