Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2020) – 128.41
MEiN – 70 pts
CiteScore (2021) – 2.0
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ISSN 1644-387X (print)
ISSN 2300-9020 (online)
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Dental and Medical Problems

2014, vol. 51, nr 4, October-December, p. 421–429

Publication type: editorial article

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Early Diagnosis Methods of Cancer Lesions in Oral Cavity – Systematic Review

Metody wczesnej diagnostyki stanów nowotworowych jamy ustnej – przegląd systematyczny

Olga Preuss1,A,B,C,D,E,F, Tomasz Smektała1,A,B,C,D,E,F, Katarzyna Sporniak-tutak1,A,B,C,D,E,F

1 Department of Dental Surgery, Pomeranian Medical University in Szczecin, Szczecin, Poland

Abstract

Oral cancers comprise between 1% and 2% of all malignant neoplasms. a delay in recognition decreases the chances of successful treatment. recently, numerous procedures have been introduced to help detect oral cancer lesions at the earliest stage. the objective of this article is to review early diagnostic methods in medical and scientific literature. a systematic literature search was carried out in MEdliNE (PubMed), MEdliNE (ovid) and the iSi Web of Knowledge from 2000 to January 10, 2013. only the articles whose main subject was the early detection of pre-cancerous and cancerous lesions were included. Staining and other methods that use light, besides detecting dysplasia and metaplasia, also increase the visibility of lesions. thanks to chemiluminescence, pathologically changed tissue becomes clearer and more visible during sample collection. incision biopsy has some disadvantages, which may lead to false negative results. these disadvantages can be reduced through careful adherence to the procedure and use of additional visualization methods, but invasiveness make this the last of choice technique. Nowadays, incision biopsy is considered the gold standard of diagnosis. However, many less invasive methods that are highly sensitive and specific also seem to be effective.

Streszczenie

Nowotwory regionu jamy ustnej stanowią 1–2% wszystkich nowotworów złośliwych. opóźnienie w postawieniu prawidłowego rozpoznania zmniejsza szanse na skuteczne leczenie. W ostatnim czasie zostały wprowadzone liczne metody wykrywania zmian nowotworowych jamy ustnej na najwcześniejszym etapie. Celem pracy jest omówienie, na podstawie piśmiennictwa, metod wczesnej diagnostyki zmian nowotworowych. Przegląd dostępnej literatury został przeprowadzony w bazach MEdliNE (PubMed), MEdliNE (ovid) oraz iSi Web of Knowledge z zastosowaniem ramy czasowej 01.01.2000–10.01.2013. do analizy zostały włączone wyłącznie artykuły, których główną tematyką było wykrywanie zmian nowotworowych na wczesnym etapie. Metody bazujące na barwieniu oraz wykorzystaniu źródeł światła umożliwiają wykrycie zarówno dysplazji i metaplazji, jak i wzmagają widoczność granic zmiany. dzięki chemiluminescencji patologicznie zmienione tkanki stają się jaśniejsze oraz bardziej widoczne podczas pobierania materiału do badania histopatologicznego. Wady biopsji nacięciowej mogą prowadzić do uzyskania wyników fałszywie negatywnych. Część tych wad może zostać zmniejszona dzięki starannemu przestrzeganiu zasad procedury oraz zastosowaniu dodatkowych metod wizualizacji, lecz inwazyjność czyni tę technikę ostatnią z wyboru. obecnie biopsja nacięciowa jest uważana za złoty standard, istnieje jednak wiele mniej inwazyjnych technik mających podobną czułość oraz i swoistość.

Key words

mouth neoplasms, staining and labeling, biopsy techniques

Słowa kluczowe

nowotwory jamy ustnej, metody barwienia tkanek, biopsja

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