Dental and Medical Problems

Dent Med Probl
Impact Factor (IF 2023) – 2.7
Scopus CiteScore (2023) – 4.0
Index Copernicus (ICV 2022) – 134.48
MNiSW – 70 pts
Average rejection rate (2023) – 82.91%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – bimonthly


 

Download original text (EN)

Dental and Medical Problems

2014, vol. 51, nr 3, July-September, p. 291–298

Publication type: editorial

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

Human Papilloma Viruses in Oral Cancer – Review of the Literature

Rola wirusów brodawczaka ludzkiego w etiopatogenezie raków jamy ustnej – przegląd piśmiennictwa

Maciej Kielan1,A,B,C,D, Monika Anna Rutkowska1,A,B,C,D, Hanna Gerber2,E,F

1 Maxillofacial Surgery Ward, 4th Military Hospital, Wroclaw, Poland

2 Department of Maxillofacial Surgery, Wroclaw Medical University, Wroclaw, Poland

Abstract

Long-term examination of squamous head and neck region carcinoma (HNSCC) epidemiology for years assumed that this is a homogeneous group of tumors. Only in recent years have they noticed some significant differences in epidemiological trends within the given anatomical regions of this area. The examination of the viral background of the cancerogenesis in this area treated mouth and larynx as a single anatomical structure, which led to overstatement of the significance of the human papilloma virus (HPV) in the scope of oral cavity cancers. The HPV prevalence within oral cavity cancers is a lot lower compared to larynx cavity cancers. The latest research points to some positive aspects stemming from a viral infection in the case of larynx cancer (deescalation of adjuvant therapy, among others) which seems to be of no significant value in preventing and curing HPV (+) carcinoma of the oral cavity. The prevalence of HPV in male patients suffering from head and neck cancers led to the extension of the current HPV prevention program, based on the vaccination of females to prevent the development of urogenital cancers, to include the recommendation of the use of the quadrivalent vaccine among young men. The work below sums up the current research regarding the role of the human papilloma viruses in oral cavity cancers.

Streszczenie

Wieloletnie badania nad epidemiologią raków płaskonabłonkowych w obrębie głowy i szyi (HNSCC) zakładały, że jest to jednorodna grupa guzów. Uważano, że obecność wirusów brodawczaka ludzkiego (HPV) w tym umiejscowieniu dotyczy niepalących, niepijących, młodych (< 40 lat), białych mężczyzn o wysokim statusie społecznym i bardziej wrażliwych na chemioi radioterapię. Dopiero w ostatnich latach zauważono znaczące różnice w trendach epidemiologicznych poszczególnych regionów anatomicznych w tej okolicy. Badania nad wirusowym podłożem kancerogenezy tego obszaru nie oddzielały od siebie regionu jamy ustnej od gardła, co w konsekwencji doprowadziło do przeszacowania rzeczywistego znaczenia wirusa HPV w nowotworach jamy ustnej. Wykrywalność HPV w rakach jamy ustnej jest o wiele mniejsza niż w rakach gardła. W świetle aktualnych badań pozytywne aspekty wynikające z infekcji wirusowej w rakach gardła (m.in. deeskalacja terapii adjuwantowej) wydają się nie mieć znaczenia w profilaktyce i terapii raków HPV (+) jamy ustnej. W pracy przedstawiono najbardziej współczesne badania dotyczące roli wirusa HPV w rakach jamy ustnej.

Key words

cancer, oral cavity, etiology, HPV

Słowa kluczowe

jama ustna, rak, nowotwór, HPV, etiopatogeneza

References (37)

  1. Zur Hasen H.: Human papillomaviruses and their possible role in squamous cell carcinomas. Curr. Top Microbiol. Immunol. 1977, 78, 1–30.
  2. Syrjanen S., Lodi G., von Bultzingslowem I., Aliko A., Arduino P., Campisi G., Challacombe S., Ficarra G., Flaitz C., Zhou H.M., Meada H., Miller C., Jontell M.: Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis. 2011, 17, Suppl. I, 58–72.
  3. Rautava J., Syrjanen S.: Biology of human papillomavirus infection in head and neck carcinogenesis. Head Neck Pathol. 2012, 6, Suppl 1, 3–15.
  4. Majchrzak E., Szybiak B., Wegner A., Pienkowski P., Pazdrowski J., Luczewski L., Sowka M., Golusinski P., Malicki J., Golusinski W.: Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature. Radiol. Oncol. 2014, 48, 1–10.
  5. Bharti A., Chotaliya K., Marfatia Y.S.: An update on oral human papillomavirus infection. Indian J. Sex Transm. Dis. 2013, 34, 77–82.
  6. Chang F., Syrjanen S.M., Kellokoski J., Syrjanen K.J.: Human papilloma virus (HPV) infections and their associations with oral diseases. J. O ral Pathol. Med. 1991, 20, 305–317.
  7. Tribius S., Hoffmann M.: Human papilloma virus infection in head and neck cancer. Dtsch. Arztebl. Int. 2013, 110, 11, 184–190.
  8. Boy S., Van Rensburg E.J., Engelbrecht S.: HPV detection in primary intra-oral squamous cell carcinomas – commensal, aetiological agent or contamination? J. O ral Pathol. Med. 2006, 35, 86–90.
  9. Miller C.S., White D.K.: Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma. A retrospective review of the literature. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 1996, 82, 57–68.
  10. Miller C., Johnstone B.M.: Human papillomavirus as a risk factor for oral squamous cell carcinoma: a metaanalysis, 1982–1997. Oral Surg. Med. Oral Pathol. Radiol. Endod. 2001, 91, 622–635.
  11. Isayeva T., Li Y., Maswahu D., Brandwein-Gensler M.: Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol. 2012, 6, 104–120.
  12. Gillison M.L., Broutian T., Picard R.K., Tong Z.Y., Xiao W., Kahle L.: Prevalence of oral HPV infection in the United States, 2009–2010. JAMA 2012, 307, 693–703.
  13. Elango K.J., Suresh A., Erode E.M.: Role of human papillomavirus in oral tongue squamous cell carcinoma. Asian Pac. J. Cancer Prev. 2011, 12, 889–896.
  14. Kristoffersen A.K., Enersen M., Kverndokk E.: Human papillomavirus subtypes in oral lesions compared to healthy oral mucosa. J. Clin. Virol. 2012, 53, 364–366.
  15. Zhang Z.Y., Sdek P., Cao J., Chen W.T.: Human papillomavirus type 16 and 18 DNA in oral squamous cell carcinoma and normal mucosa. Int. J. O ral Maxillofac. Surg. 2004, 33, 71–79.
  16. Summersgil K.F., Smith E.M., Levy B.T., Allen J.M., Haugen T.H., Turek L.P.: Human papillomavirus in the oral cavities of children and adolescents. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2001, 91, 62–69.
  17. Kojima A., Maeda H., Kurahashi N., Sakagami G., Kubo K., Yoshimoto H., Kameyama Y.: Human papillomavirus in the normal oral cavity of children in Japan. Oral Oncol. 2003, 39, 821–828.
  18. Durzyńska J., Pacholska-Bogalska J., Kaczmarek M.: HPV genotypes in the oral cavity/oropharynx of children and adolescents: cross-sectional survey in Poland. Eur. J. Pediatr. 2011, 170, 757–761.
  19. Du J., Nordfors C., Ahrlund-Richter A., Sobkowiak M.: Prevalence of oral human papillomavirus infection among youth, Sweden. Emerg. Infect. Dis. 2012, 18, 1468–1471.
  20. Fakhry C., D’Souza G., Sugar E., Weber K., Goshu E., Minkoff H., Wright R., Seaberg E., Gillison M.: Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency viruspositive and -negative women. J. Clin. Microbiol. 2006, 44, 4479–4485.
  21. Vogt S.L., Gravitt P., Martinson N.A., Hoffmann J., D’Souza G.: Concordant oral-genital HPV infection in South Africa couples: evidence for transmission. Front Oncol. 2013, 3, 303–309.
  22. Romabaldi R.L., Serafini E.P., Mandelli J., Zimmermann E., Losquiavo K.: Perinatal transmission of human papillomavirus DNA. Virol. J. 2009, 6, 83–90.
  23. Beachler D.C., D’souza G.: Oral HPV infection and head and neck cancers in HIV-infected individuals. Curr. Opin. Oncol. 2013, 25, 503–510.
  24. Golusiński P., Lamperska K., Brakkhuis B., Snijders P., Pazdrowski J., Pieńkowski P., Łuczewski Ł., Golusiński W.: Prevalence and role of papillomavirus infection in head and neck cancers. Pol. Przeg. Otolaryngol. 2012, 1, 244–251 [in Polish].
  25. Mork J., Lie A., Glattre E., Hellmans G., Jellum E., Koskela P.: Human papillomavirus infection as a risk factor for squamous cell carcinoma of the head and neck. N. Engl. J. Med. 2001, 344, 1125–1131.
  26. Badaracco G., Rizzo C., Mafera B.: Molecular analyses and prognostic relevance of HPV in head and neck tumours. Oncol. Rep. 2007, 17, 931–939.
  27. Gillison M.L., Koch W.M., Capone R.B.: Evidence for a causal association between human papillomavirus and subset of head and neck cancers. J. Natl. Cancer Inst. 2000, 92, 709–720.
  28. Thibaudeau E., Fortin B., Coutlee F.: HPV Prevalence and prognostic value in a prospective cohort of 255 patients with locally advanced HNSCC: a single-centre experience. Int. J. O tolaryngol. 2013, 437818.
  29. O’Sullivan B., Huang S.H., Siu L.L., Waldron J., Zhao H., Perez-Ordonez B.: Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J. Clin. Oncol. 2013, 31, 543–550.
  30. Markopoulos A.: Role of human papillomavirus in the pathogenesis of oral squamous cell carcinoma. World J. Exp. Med. 2012, 2, 4, 65–69.
  31. Kaminagakura E., Villa L.L., Andreoli M.A.: High-risk human papillomavirus in oral squamous cell carcinoma of young patients. Int. J. Cancer. 2012, 130, 1726–1732.
  32. Sugiyama M., Bhawal U.K., Kawamura M.: Human papillomavirus-16 in oral squamous cell carcinoma: clinical corelates and 5-year survival. Br. J. O ral Maxillofac. Surg. 2007, 45, 116–122.
  33. Smith E.M., Rubenstein L.M., Haugen T.H.: Complex etiology underlines risk and survival in head and neck cancer human papillomavirus, tobacco and alcohol: a case for multifactor diseases. J. O ncol. 2012, 571862.
  34. Lee L.A., Huang C.G., Liao C.T.: Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival. PloS One. 2012, 7, 7.
  35. Colon-Lopez V., Quinones-Avila V., Del Toro-Mejias L., Reyes K.: Oral HPV infection in a clinic-based sample of Hispanic men. BMC Oral Health 2014, 14.
  36. Rosenquist K., Wennerberg J., Schildt E.B.: Oral status, oral infections and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma. A population-based case-control study in southern Sweden. Acta Otolaryngol. 2005, 125, 1327–1336.
  37. Bertolus C., Goudot P., Gessain A., Berthet N.: Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma. Infect Agents Cancer 2012, 7, 13–18.
© Wroclaw Medical University