Dental and Medical Problems

Dent. Med. Probl.
Index Copernicus (ICV 2019) – 118.76
MNiSW – 20
CiteScore (2020) – 1.2
Average rejection rate (2020) – 88.71%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2012, vol. 49, nr 2, April-June, p. 299–304

Publication type: review article

Language: Polish

Cytotoksyczność współcześnie stosowanych systemów wiążących – na podstawie piśmiennictwa

Cytotoxicity of Current Adhesive Systems – Based on Literature Review

Elżbieta Jodkowska1,A-F

1 Zakład Stomatologii Zachowawczej Instytutu Stomatologii Warszawskiego Uniwersytetu Medycznego

Streszczenie

Wszystkie współcześnie stosowane materiały dentystyczne w różnym stopniu uwalniają substancje do środowiska jamy ustnej. Znajomość podstawowych reguł ich zastosowania pozwoli zapobiec temu niepożądanemu procesowi lub przynajmniej go ograniczyć. Na podstawie piśmiennictwa zwrócono uwagę na możliwość wystąpienia reakcji ubocznych środowiska jamy ustnej na systemy wiążące. Badania in vitro i in vivo potwierdziły, że uwalniające się monomery powodują uszkodzenia chemiczne w hodowlach komórkowych i komórkach miazgi, penetrując przez tkankę zębinową, zakłócają metabolizm komórek. Oprócz molekularnej cytotoksyczności dużych stężeń monomerów, małe stężenia mogą zaburzyć metabolizm, homeostazę komórkową, indukować apoptozę lub zatrzymać cykl komórkowy. Żywice Bis-GMA, HEMA, TEGDMA zmieniają ekspresję genów, których produkty biorą udział w regulacji wzrostu komórki, proliferacji i zróżnicowaniu, reaplikacji i naprawie DNA.

Abstract

All dental biomaterials release substances to the oral cavity with varying degree. Knowing the basic rules of internal use enables to prevent such adverse reactions, or at least minimize them. Based on literature review, a potential occurrence of side effects of the adhesive systems on the oral cavity, is described. In vitro and in vivo studies have confirmed that released monomers cause chemical damage in cells cultures and in pulp cells. Penetrating through tooth tissue monomers disrupt meous monomers at high concentration, low concentration can have deleterious effect on the metabolism, cellular homeostasis, can also trigger apoptosis or cell cycle delay. Bis-GMA, HEMA, TEGDMA can induce the expression of the genes whose products are involved in regulation of cell growth, gene expression, proliferation and differentiation, reapplication and DNA repair.

Słowa kluczowe

zębinowe systemy wiążące, cytotoksyczność, zębina

Key words

dentinal adhesive systems, cytotoxicity, dentin

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