Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2020) – 128.41
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI – 0.5
Average rejection rate (2021) – 81.35%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2010, vol. 47, nr 2, April-June, p. 206–213

Publication type: review article

Language: Polish

Cytokiny w płynie kieszonki dziąsłowej jako potencjalne markery diagnostyczne i prognostyczne zapalenia przyzębia

Cytokines in Gingival Crevicular Fluid as Potential Diagnostic and Prognostic Markers of Periodontitis

Łukasz Konopka1,, Ewa Brzezińska-Błaszczyk1,

1 Zakład Immunologii Doświadczalnej, Uniwersytet Medyczny w Łodzi

Streszczenie

Powszechnie uważa się, że chociaż czynnikiem inicjującym rozwój chorób przyzębia są bakterie, to procesy destrukcyjne w tkankach są wynikiem odpowiedzi immunologiczno-zapalnej gospodarza. Podczas odpowiedzi zapalnej dochodzi do syntezy różnych czynników humoralnych, a następnie ich wydzielania do otaczających tkanek. Mimo że wiedza na temat etiologii i patomechanizmu chorób przyzębia jest coraz większa, diagnostyka tych chorób ciągle jest oparta na klasycznych kryteriach klinicznych. Taka diagnostyka periodontologiczna jest z natury ograniczona, bowiem pozwala ocenić raczej historię choroby niż stan obecny. Dlatego istnieje konieczność wprowadzenia nowych testów diagnostycznych, które pozwoliłyby ocenić nasilenie procesu chorobowego, przewidzieć progresję choroby oraz ocenić rezultaty prowadzonej terapii. Wydaje się obecnie, że ilościowa i jakościowa analiza specyficznych składników płynu kieszonki dziąsłowej (GCF) mogłaby być użyteczna w ocenie stanu zdrowia tkanek przyzębia. Biorąc pod uwagę, że niezwykle istotnymi czynnikami humoralnymi modulującymi przebieg procesów zapalnych, także w tkankach przyzębia, są cytokiny w artykule oceniono przydatność oceny stężenia cytokin w GC F w diagnostyce periodontologicznej. Szczególną uwagę poświęcono cytokinom prozapalnym, takim jak interleukina (IL)-1β, IL-18, IL-6 i czynnik martwicy nowotworu (TNF), niektórym chemokinom, to jest IL-8, RANTES i białko chemotaktyczne dla monocytów (MCP-1), jak również cytokinom przeciwzapalnym, takim jak IL-10 i IL-4.

Abstract

It is widely accepted that although bacteria are initiating agents in periodontal diseases, the host response to the pathogenic infection is critical for disease progression. The host inflammatory response to bacterial infection involves the production of a variety of humoral factors and their release into surrounding tissues. Despite increased understanding of the etiology and pathomechanism of periodontal diseases, the diagnosis and classification of these conditions are still almost entirely based on traditional clinical assessments. This diagnostic procedure is inherently limited, in that only disease history, not current disease status, can be assessed. Therefore, there is a need for the development of new diagnostic tests that can detect the severity of disease, predict future disease progression, and evaluate the response to periodontal therapy. Nowadays it seems that quantitative and qualitative analysis of specific constituents in gingival crevicular fluid (GC F) can be useful for the evaluation of periodontal health status. Taking into account that cytokines are central to the pathogenesis of inflammatory processes, including periodontal diseases, in this review the authors discussed the usefulness of cytokine level evaluation in GCF for periodontal disease diagnosis. The authors described proinflammatory cytokines, such as interleukin (IL)-1β, IL-18, IL-6 and tumor necrosis factor (TNF), some chemokines, that is IL-8, RANTES and monocyte chemoattractant protein (MCP-1), as well as anti-inflammatory cytokines such as IL-10 and IL-4.

Słowa kluczowe

zapalenie przyzębia, cytokiny, płyn kieszonki dziąsłowej

Key words

periodontitis, cytokines, gingival crevicular fluid

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