Dental and Medical Problems

Dent Med Probl
Index Copernicus (ICV 2020) – 128.41
MEiN – 70 pts
CiteScore (2021) – 2.0
JCI – 0.5
Average rejection rate (2021) – 81.35%
ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2010, vol. 47, nr 2, April-June, p. 199–205

Publication type: review article

Language: Polish

Zastosowanie biochemicznych markerów obrotu kostnego w medycynie ogólnej i stomatologii

Use of Biochemical Markers of Bone Turnover in General Medicine and Dentistry

Piotr Jurkowski1,, Elżbieta Mierzwińska-Nastalska1,, Jolanta Kostrzewa-Janicka1,

1 Katedra Protetyki Stomatologicznej IS Warszawskiego Uniwersytetu Medycznego

Streszczenie

W pracy przedstawiono współczesne zastosowanie markerów obrotu kostnego w medycynie ogólnej i stomatologii. Ich stężenie mierzy się w surowicy, moczu lub płynie stawowym. Wskazuje on na tempo syntezy lub resorpcji tkanki chrzęstnej i kostnej. Informacje te służą do oceny skuteczności leczenia i ryzyka złamań u pacjentów z osteoporozą oraz monitorowania rozwoju chorób nowotworowych kości. W stomatologii dokonuje się pomiarów markera CTX u pacjentów leczonych bisfosfonianami, przed zabiegami chirurgicznymi szczęk. Pozwala to zapobiec powstaniu pozabiegowej martwicy kości. Prowadzone są również prace nad wykorzystaniem wskaźników resorpcji chrząstki do wczesnej diagnostyki osteoartrozy stawów, w tym stawu skroniowo-żuchwowego. Wczesne wykrycie niewidocznych jeszcze radiologicznie nieprawidłowości umożliwiłoby wprowadzenie odpowiedniego leczenia i zapobiegło rozwojowi nieodwracalnych zmian zwyrodnieniowych (Dent Med. Probl. 2010, 47, 2, 199–205).

Abstract

In this article, contemporary use of bone turnover markers in medicine and dentistry was presented. Their level is measured in serum, urine and synovial fluid. It shows the rate of cartilage and bone synthesis as well as resorption. This information is used to estimate effectiveness of treatment and risk of fractures in osteoporotic patients. It enables also to monitor bone neoplasm progression. In dentistry, measurement of CTX marker in patients on biophosphonate theraphy is practiced, before surgical procedures on maxilla and mandibule. It helps to avoid after-operation bone necrosis. There have been many studies carried on the use of cartilage resorption markers for early joint osteoarthrosis diagnosis, including TMJ. Early detection of radiologically invisible disorders would enable to introduce proper treatment and prevent irreversible degenerative changes (Dent Med. Probl. 2010, 47, 2, 199–205).

Słowa kluczowe

markery obrotu kostnego, osteoartroza stawów skroniowo-żuchwowych

Key words

bone turnover markers, temporomandibular joint osteoarthtosis

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