Dental and Medical Problems

Dent Med Probl
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ISSN 1644-387X (print)
ISSN 2300-9020 (online)
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Dental and Medical Problems

2016, vol. 53, nr 3, July-September, p. 332–337

doi: 10.17219/dmp/63932

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Serum Concentration of C-Reactive Protein in Patients Treated for Acute and Chronic Odontogenic Infections

Stężenie białka C-reaktywnego w surowicy krwi pacjentów leczonych z powodu ostrych i przewlekłych zębopochodnych stanów zapalnych

Adam Jakimiak1,B,C,D,E,F, Martyna Kochańska2,B,C,D, Monika Michalska2,B,C,D, Mateusz Celej2,B,C,D, Andrzej Wojtowicz1,E,F, Wojciech Popowski1,A,B,C,D,E,F

1 Dental Surgery Department, Medical University of Warsaw, Warsaw, Poland

2 Medical University of Warsaw, Warsaw, Poland

Abstract

Background. C-reactive protein (CRP) performs many important functions in the body, among which the binding, detoxification and elimination of tissue breakdown products seem to be the most important ones. CRP measurement is a fast and simple method for detecting inflammatory processes.
Objectives. The aim of the study was to determine the serum CRP level in peripheral blood during acute and chronic odontogenic infections before and after surgical treatment.
Material and Methods. Serum CRP levels were determined by immunochromatography. Blood samples were collected from the fingertip of study participants, and Actim CRP dipstick tests were performed prior to, 24 hours after and 7 days after surgical treatment.
Results. There were no significant differences (p = 0.132) between the baseline CRP level and after 24 hours in the entire group with chronic infections. In patients with non-elevated baseline CRP, surgical intervention caused a CRP increase after 24 hours in 8 out of 11 of the subjects. In chronic periapical periodontitis, CRP was significantly lower after 7 days in 19 out of 20 subjects (p = 0.005). In acute infections, CRP was markedly elevated. After 7 days of therapy, a statistically significant (p = 0.0002) reduction of CRP by 40 mg/L was recorded in 16 subjects, however, CRP remained elevated compared to the normal range in 13 cases.
Conclusion. Our study revealed significant CRP level variations depending on the type of odontogenic infection, treatment time and treatment itself. Although acute inflammation induced higher CRP values, chronic inflammation was still noticeable in the collected data.

Key words

C-reactive protein, acute odontogenic infections, chronic odontogenic infections, acute phase reaction

Słowa kluczowe

białko C-reaktywne, ostry zębopochodny stan zapalny, przewlekły zębopochodny stan zapalny, reakcja ostrej fazy

References (18)

  1. Bansal T., Pandey A., Deepa D., Asthana A. K.: C-reactive protein (CRP) and its association with periodontal disease: A brief review. J. Clin. Diagn. Res. 2014, 8, 7, ZE21–ZE24.
  2. Pepys M.B., Hirschfield G.M.: C-reactive protein: A critical update. J. Clin. Invest. 2003, 111, 1805–1812.
  3. Pradhan A.D., Manson J.E., Rifai N., Buring J.E., Ridker P.M.: C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA, 2001, 286, 327–334.
  4. Orzędała-Koszel U., Bachanek T., Kaczmarek-Borowska B.: C-reactive protein as a diagnostic factor in inflammatory processes of oral cavity and neoplasma diseases. Dent. Med. Probl. 2005, 42, 131–136 [in Polish].
  5. Nakayama T., Sonoda S., Urano T., Yamada T., Okada M.: Monitoring both serum amyloid protein Aand C-reactive protein as inflammatory markers in infectious diseases. Clin. Chem. 1993, 39, 293–297.
  6. Gomes-Filho I.S., Freitas Coelh, J.M., da Cruz S.S., Passos J.S., Teixeira de Freitas C.O., Aragão Farias N.S., Barreto M.L.: Chronic periodontitis and C-reactive protein levels. J. Periodontol. 2011, 82, 969–978.
  7. Pepys M.B.: C-reactive protein fifty years on. Lancet, 1981, 317, 653–657.
  8. Mold C., Gurulé C., Otero D., Du Clos T.W.: Complement-dependent binding of C-reactive protein complexes to human erythrocyte CR1. Clin. Immunol. Immunopathol. 1996, 81, 153–160.
  9. Libby P., Ridker, P.M.: Inflammation and atherosclerosis: Role of C-reactive protein in risk assessment. Am. J. Med. 2004, 116, 9–16.
  10. Kuras M., Sokalski J., Szubert P.: Changes of C-reactive protein concentrations following surgical procedures in oral cavity. Nowiny Lek. 2009, 78, 129–134 [in Polish].
  11. Czechowska E., Kuras M., Sokalski J.: Acute phase proteins as inflammatory markers in selected diseases and in treatment attenuation in the oral cavity – literature review. Dent. Med. Probl. 2012, 49, 57–61.
  12. Mirhosseini S.J., Forouzannia S.K., Ali-Hassan-Sayegh S., Ravan H.V., Abdollahi M.H., Mozayan M.R.: Preoperative C-reactive protein can predict early clinical outcomes following elective off-pump CABG surgery in patients with severe left ventricle dysfunction. Saudi J. Anaesth. 2012, 6, 327–331.
  13. Androsz-Kowalska O., Jankowski K., Rymarczyk P., Pruszczyk P., Górska R.: Evaluation of periodontal status and analysis of relationship between periodontal clinical parameters and selected standard inflammatory parameters in patients with coronary heart disease and chronic periodontitis. J. Stoma. 2011, 64, 200–211 [in Polish].
  14. Zaremba M.L.: Periodontal diseases and the development of inflammatory response. Czas Stomatol. 2009, 62, 531–548 [in Polish].
  15. Watts A., Crimmins E.M., Gatz M.: Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease. Neuropsychiatr. Dis. Treat. 2008, 4, 865–876.
  16. Dražić R., Jurišić M., Marković A., Colić S., Gačić B., Stojčev-Stajčić L.: C-reactive protein as an inflammatory marker in monitoring therapy effectiveness of acute odontogenic infections. Srp. Arh. Celok. Lek. 2010, 139, 446–451.
  17. Fedele S., Sabbah W., Donos N., Porter S., D’Aiuto F.: Common oral mucosal diseases, systemic inflammation, and cardiovascular diseases in a large cross-sectional US survey. Am. Heart J. 2011, 161, 344–350.
  18. Kallergis E.M., Manios E.G., Kanoupakis E.M., Mavrakis H.E., Kolyvaki S.G., Lyrarakis G.M., Vardas P.E.: The role of the post-cardioversion time course of hs-CRP levels in clarifying the relationship between inflammation and persistence of atrial fibrillation. Heart, 2008, 94, 200–204.