Dental and Medical Problems

Dent Med Probl
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CiteScore (2021) – 2.0
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ISSN 1644-387X (print)
ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2016, vol. 53, nr 3, July-September, p. 332–337

doi: 10.17219/dmp/63932

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Serum Concentration of C-Reactive Protein in Patients Treated for Acute and Chronic Odontogenic Infections

Stężenie białka C-reaktywnego w surowicy krwi pacjentów leczonych z powodu ostrych i przewlekłych zębopochodnych stanów zapalnych

Adam Jakimiak1,B,C,D,E,F, Martyna Kochańska2,B,C,D, Monika Michalska2,B,C,D, Mateusz Celej2,B,C,D, Andrzej Wojtowicz1,E,F, Wojciech Popowski1,A,B,C,D,E,F

1 Dental Surgery Department, Medical University of Warsaw, Warsaw, Poland

2 Medical University of Warsaw, Warsaw, Poland


Background. C-reactive protein (CRP) performs many important functions in the body, among which the binding, detoxification and elimination of tissue breakdown products seem to be the most important ones. CRP measurement is a fast and simple method for detecting inflammatory processes.
Objectives. The aim of the study was to determine the serum CRP level in peripheral blood during acute and chronic odontogenic infections before and after surgical treatment.
Material and Methods. Serum CRP levels were determined by immunochromatography. Blood samples were collected from the fingertip of study participants, and Actim CRP dipstick tests were performed prior to, 24 hours after and 7 days after surgical treatment.
Results. There were no significant differences (p = 0.132) between the baseline CRP level and after 24 hours in the entire group with chronic infections. In patients with non-elevated baseline CRP, surgical intervention caused a CRP increase after 24 hours in 8 out of 11 of the subjects. In chronic periapical periodontitis, CRP was significantly lower after 7 days in 19 out of 20 subjects (p = 0.005). In acute infections, CRP was markedly elevated. After 7 days of therapy, a statistically significant (p = 0.0002) reduction of CRP by 40 mg/L was recorded in 16 subjects, however, CRP remained elevated compared to the normal range in 13 cases.
Conclusion. Our study revealed significant CRP level variations depending on the type of odontogenic infection, treatment time and treatment itself. Although acute inflammation induced higher CRP values, chronic inflammation was still noticeable in the collected data.

Key words

C-reactive protein, acute odontogenic infections, chronic odontogenic infections, acute phase reaction

Słowa kluczowe

białko C-reaktywne, ostry zębopochodny stan zapalny, przewlekły zębopochodny stan zapalny, reakcja ostrej fazy

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